New Horizons GIST 2020/2021

New Horizons GIST  – Special Topic: Mutational Analysis in GIST as a guide for the right therapy - May 7, 2021

For several years now NEW HORIZONS GIST is the most important global platform for GIST patient advocates with a focus on discussing critical information about GIST that impacts the global GIST patient and medical communities. Due to the current coronavirus pandemic, the 2020 New Horizons GIST conference was held as a virtual conference in September 2020 (see a report about the meeting and its very interesting sessions pdf here (1.53 MB)  (pdf download) as well as all available ressources including presentations and recordings here).

In an extra 2 hours online meeting at 7th of May we focused on
"Mutational Analysis in GIST as a guide for the right therapy" as a special topic.

The programme included the following talks:

Introduction to the topic of Mutational Analysis
>> See slides ( pdf pdf download (840 KB) )
Markus Wartenberg, SPAEN		 Recording
Key Notes Mutations and Mutational Analysis in GIST   
 

GIST-Pathologist: Dr. Andrew Rosenberg, USA

- What is the role of a pathologist in the interdisciplinary GIST team?

- How do GISTs arise genetically / biologically?

- What types of mutations are there in GIST?

- Closer look on mutations in KIT/PDGFRA?

- What is the difference between primary and secondary mutations?

- Does the mutation have an impact on the course of the disease / prognosis?

GIST-Pathologist: Eva Wardelmann, GER

- In simple steps: How does such a mutational analysis work?

- Costs, time and efforts of mutational analysis?

- What role does/can liquid biopsy play in GIST?
Is this a scientific procedure or clinical practice?

- What do we know about rare mutations -
   not localized in KIT or PDGFRA?

- What are the three most burning (scientific) questions
in GIST from the perspective of a researching pathologist?

  Recording
 Key Notes Impact of mutations in clinical practice  
 

GIST-Expert/-Oncologist: Rashmi Chugh, USA
>> See slides ( pdf pdf download (1.77 MB) )

The influence of the mutation result on the choice of therapy

- In which cases do primary mutations guide the choice of therapy?

- What role do secondary mutations play in therapy decision?

- What about treatment option for specific, very rare mutations,
   such as BRAF, SDH- or NTRK?

GIST-Expert/-Oncologist: Peter Reichardt, GER

Patient cases with rare mutations in which the quality
of therapy management has made a clear difference?

  Recording

 Country Presentations on experiences with mutational analysis

 Recording

Header NHGIST 2020 Berlin

The corona virus has dramatically changed our private lives and our lives as Patient Advocates worldwide. So, also NEW HORIZONS GIST 2020 was held virtually! 
As many of you have already experienced: NEW HORIZONS GIST is a great opportunity where “GIST Patient Advocates / GIST Patient Group Leaders” from around the world are coming together - this time virtually!

NH GIST 2020 Screenshot participants
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Over 60 particpants from almost 20 countries came together online. 10 speakers were joining us!
 
Speakers NH 2020
The first ever virtual New Horizons GIST Patient Advocacy Meeting has come to an end - we had three intensive half days with brilliant speakers and a lot of interesting questions from the community. Many international - LEADING GIST-Experts have provided insights into GIST basics including diagnosis, treatment, care and research issues as well as more in-depth knowledge and latest developments and most pressing questions. At the maximum we had 63 participants which is the highest number of attendees at a New Horizons GIST meeting ever!
>> See the presentations and recordings below and read our full New Horizons GIST report here.
 
We also plan to have special "Patient Advocacy Sessions" (Capacity Building) for GIST and Sarcoma Patient Advocates later in this year or early 2021. More information will follow shortly.
If you have any questions, please e-mail to This email address is being protected from spambots. You need JavaScript enabled to view it.
 

Ressources

 
 
>> Slidedecks of the presentations for download

pdf GIST Episode 1: Introduction – Overview (2.32 MB)
Speaker: Hans Gelderblom, NL

pdf GIST Episode 2: Biology – Genetics – Pathology
(2.61 MB) Speaker: David Josephy, CDN

pdf GIST Episode 3: Localized, operable primary tumor (2.41 MB)
Speaker: Peter Reichardt, DE

pdf GIST Episode 4: Metastatic (advanced) disease
(3.31 MB) Speaker: Albiruni Razak, CDN

pdf GIST Episode 5: Progression of metastatic disease under drug treatment (1.77 MB)
Speaker: Breelyn Wilky, US

pdf GIST Episode 6: Introducing new treatment options in GIST (1.49 MB)
Speaker: Jon Trent, US

pdf GIST Episode 7: Challenges in approaching a non-KIT/PDGFR mutated GIST (2.59 MB)    
Speaker: Ramesh Bulusu & Ruth Casey, UK        

pdf GIST Episode 8: Following the research journey in GIST (1.50 MB)
Speaker: Robin Jones, UK

pdf GIST Episode 9: Quality of diagnosis, treatment & care (3.89 MB)
Speaker: Gina D'Amato, US
 

 >> Video recordings of the presentations

New Horizons GIST 2020: Episode 1 - Introduction & Overview

Speaker: Hans Gelderblom, The Netherlands

pdf Presentation Download (2.32 MB)

New Horizons GIST 2020: Episode 2 - Biology, Genetics, Pathology

Speaker: David Josephy, Canada

pdf Presentation Download (2.61 MB)

New Horizons GIST: Episode 3 - Localized operable primary tumour

Speaker: Peter Reichardt, Germany

pdf Presentation Download (2.41 MB)

New Horizons GIST 2020: Episode 4 - Metastatic (advanced) disease

Speaker: Albiruni Razak, Canada

pdf Presentation Download (3.31 MB)

New Horizons GIST 2020: Episode 5 - Progression of metastatic disease under drug treatment

Speaker: Breelyn Wilky, USA

pdf Presentation Download (1.77 MB)

New Horizons GIST 2020: Episode 6 - Introducing new treatment options in GIST

Speaker: Jonathan Trent, USA

pdf Presentation Download (1.49 MB)

New Horizons GIST 2020: Episode 7 - Challenges in approaching non KIT/PDGFR mutated GIST

Speaker: Ramesh Bulusu & Ruth Casey, UK

pdf Presentation Download (2.59 MB)

New Horizons GIST 2020: Episode 8 - Following the research journey

Speaker: Robin Jones, UK

pdf Presentation Download (1.50 MB)

New Horizons GIST 2020: Episode 9 - Quality of diagnosis, treatment & care

Speaker: Gina D'Amato, US

pdf Presentation Download (3.89 MB)

 >> Life Raft Group: Summary of New Horizons GIST 2020

Find more videos on our Youtube Channel! 

Previous New Horizons GIST Meetings

For several years now, NEW HORIZONS GIST is the most important global annual conference for GIST patient advocates. At NEW HORIZONS GIST, patients from the global GIST patient community come together, can interact with top GIST experts, have access to state‐of‐the‐art medical and scientific information and can exchange best practice in patient advocacy among each other. The conference is a balanced symbiosis of medical content, advocacy topics and capacity building sessions. It is held every year and organised by either American Groups (The Life Raft Group/Alianza GIST) or European Groups in cooperation with SPAEN.

NEW HORIZONS GIST 2020 was held virtually due to COVID-19. Please see all relevant information here.


NEW HORIZONS GIST 2018 was held in Vienna, Austria, in September 2018

 
NEW HORIZONS GIST 2017 was held in Wayne, New Jersey, USA from October 1-3, 2017.


NEW HORIZONS GIST 2016 was held in Sitges/Barcelona, Spain from May 18-21, 2016.